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Machanism
- Matrix metalloproteinases (MMP) damages skin collagen
- TNF-α is induced together with interleukin-6 (IL-6) that plays a major regulatory role in acute local and systemic inflammatory responses (Z. Xing et al., 1998)
- IL-6 is thought to have both pro- and anti-inflammatory effects. (K. Eder et al., 2009)
- IL-10 plays a suppressing role in inflammatory responses. It down regulates the expression of TNF-α in monocytes and macrophages. (G.Del Prete et al., 1993)
- IL-6 and TNF-α cytokines induced by LPS were both found significantly inhibited by IL-10 in macrophage cell lines. (D. F. Fiorentino et al., 1991)
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